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11/16 Disorders of the Optic Nerve
Neuro
24
Medical
Graduate
11/20/2011

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Cards

Term
optic nerve head/disc
Definition
part of optic nerve visible by ophthalmoscopy

flat, round ring of neural tissue (neuroretina rim) and central depression (physiological cup)
Term
neuroretina rim
Definition
pinkish color from capillaries

distinct border with surrounding retinal tissue

slightly elevated on nasal side
Term
physiologic cup
Definition
round and white

should be no more than 1/2 the diameter of the optic disc

cup:disc ratio
Term
central or centrocecal scotoma
Definition
visual deficit in center of visual gield, in the "papillomacular bundle"

toxic/nutritional/metabolic, inflammatory, compressive disorders
Term
arcuate/altitudinal scotoma
Definition
deficit gathered around central papillodmacular region

ischemic disorders and papilledema
Term
temporal wedge scotoma
Definition
deficit in bundled wedge-like pattern (apex at blind spot)

congenital malformations (dysplagias) of the optic nerve
Term
optic disc changes
Definition
neuroretinal rim pallor

elevation

excavation of the cup

dysplasia
Term
neuroretinal rim palloe
Definition
rim is white instead of pink

suggests loss of axons - congenital or acquired

takes at least 4 weeks to develop
Term
optic disc elevation
Definition
underlying pathology of EDEMA

inflammation, ischemia, neoplastic infiltration, increased ICP )padilledema)

congenital variants
Term
excavation of cup
Definition
widening and deepening of physiologic cup because of atrophy pf neuroretinal ring

only occurs if the process destroys not only axons but their supporting glial elements

glaucoma; ophthalmic artery occlusion (giant cell arteritis); congenital dysplasia ("coloboma")
Term
optic disc dysplasia
Definition
optic discs may be malformed at birth

too small - hypoplastic

excavated - colobomatous

tilted - dysverted

elevations
Term
optic nerve disorders
Definition
optic neuritis
ischemic optic neuropathy
compression by a mass
infiltration by cancer
systemic toxic-nutritional-metabolic disorder
increased ICP
glaucoma
Term
optic neuritis
Definition
age 15-45, F>M

subacute monocular vision loss, pain around eye

may be only a manifestation or part of systemic illness, MS

ADP, reduced actuiy, *nerve fiber bundle defect*, optic disc normal or swollen
Term
ischemic optic neuropathy
Definition
infarction of optic nerve

arteritic (giant cell) and non-arteritic forms

vision does not recover
Term
giant cell arteritis
Definition
arteritic ischemic optic neuropathy

over age 70, F=M

aches, malaise, jaw claudication, anorexia, poor appetite, anemia

sudden severe visions loos, ADP

elevated sed rate and CRP

positive temporary artery biopsy to make diagnosis; high dose steroids to prevent spread to other eye
Term
non-arteritic ischemic optic neuropathy
Definition
10x more common

age over 40, M=F, DB/HTN/smoking, etc

less severe vision loss, compromised vessels, "lacunae" of optic nerve

segmentally swollen optic disc, usually nonprogressive but no recovery
Term
compression by a mass
Definition
sudden or slow loss, with or without pain

and age, gender

usually intracranial, affecting chiasm, so visual field defect is HEMIANOPIC

brain imaging crucial

pituitary adenoma, meningioma, pilocytic astrocytoma, aneurysm, cyst
Term
infiltration by cancer
Definition
subacute visual loss, usually severe

may have no other new symptoms

any age or gender, usually known history of cancer

optic disc often looks normal

imaging and LP - meningeal enhancement, pleocytosis, high protein
Term
systemic toxic-nutritional metabolic conditions
Definition
slowly progressive, symmetrical vision loss

central of centrocecal scotomas

enthambutal, methanol, alcohol, poor diet

mitochondrial dysfunction: Leber hereditary optic neuropathy

dilated optic disc blood vessels, thickened peripapillary nerve fiber layer

vision loss usually profound and irreversible
Term
papilledema

increased ICP
Definition
usually binocular but may be asymmetrical

edema initially spares center of disc

visual function relatively preserved (unless chronic)

space-taking mass, meningitis, dural venous sinus thrombosis, cerebral edema, idiopathic intracranial HTN
Term
glaucoma
Definition
4 types:

-primary open angle

-secondary

-angle closure (acute presentation)

-congenital
Term
primary open angle glaucoma
Definition
most common form, 2% prevalence world wide

mostly over age 40, M=F

painless, slowly progressive optic disc excavation and visual field loss that spares the papillomacular bundles

impaired aqueous drainage though trabecular meshwork, increased intraocular pressure
Term
primary open angle glaucoma

clinical features and treatment
Definition
1. pathologic excavation of the optic disc (enlarged cup, effacement of rim) cup:disk 2. elevated intraocular pressure

tx: lower intraocular pressure!
-topical medications
-surgery to improve drainage if meds fail
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