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100814 - Trematodes
N/A
33
Immunology
Graduate
10/12/2014

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Term
Trematode (flukes) general apperance
Definition
Oval, leaf-shaped
Term
Types of flukes (3)
Definition
Blood fluke, lung fluke, liver fluke
Term
ALL trematodes are what kind of infection?
Definition
Tissue
Term
Schistosomiasis - mode of transmission
Definition
Contact (through skin by cercariae)
Term
Schistosomiasis - geographical distribution
Definition
S. mansoni (Africa, Eastern S. America); S. japonicum (SE Asia); S. haematobium (Africa)
Term
Schistosomiasis - 3 varieties
Definition
S. mansoni (mesenteric veins), S. japonicum (mesenteric veins), S. haematobium (bladder veins)
Term
Schistosomiasis - intermediate/definite hosts, life cycle
Definition
Eggs shed in feces (Mansoni, japonicum) or urine (haematobium); ingested by SNAILS (Intermediate), who produce cercariae; penetrates HUMAN (Definitive) skin
Term
Schistosomiasis - adult form lives how long? Sheds how many eggs per day? What is responsible for pathology?
Definition
Adult form lives 20-30 years. Produces 100s-1000s eggs/day; 50% of these eggs die, creating inflammation and pathology
Term
S. mansoni/japonicum - Sx
Definition
Portal hypertension, ascites, esophageal varicose veins, liver fibrosis, *pipestem fibrosis* - excessive fibrous tissues around portal veins/bile ducts
Term
S. haematobium - Sx
Definition
Hematuria, bladder fibrosis, obstructive uropathy. (Rare: renal failure, hydronephrosis, carcinoma)
Term
Schistomiasis - Dx
Definition
Eggs in feces (M/J) or urine (H). ELISA can be used for all. Distinctive egg shapes for all three
Term
S. mansoni egg
Definition
Lateral spine
Term
S. japonicum egg
Definition
Lateral SMALL spine
Term
S. haematobium egg
Definition
Terminal spine
Term
Paragonimus westermani - name, mode of transmission, classification
Definition
Lung Fluke, ingestion, tissue disease
Term
P. westermani - geographical distribution
Definition
SE Asia, Japan
Term
P. westermani - intermediate/definite host, life cycle
Definition
Eggs shed in feces OR sputum; ingested by SNAIL (intermediate host), who releases cercariae that are ingested by CRUSTACEAN (2nd intermediate host), and those are ingested by HUMANS (definitive host)
Term
P. westermani - infectious form
Definition
Metacercariae (in uncooked/contaminated crustaceans). Snails carry cercariae but unlike Schistosomes, this is not the infectious form
Term
P. westermani - migration in humans
Definition
Swallowed --> to duodenum, or tissue invasion --> to lung
Term
P. westermani - Sx (Acute and chronic)
Definition
Acute - diarrhea, abdominal pain, fever, cough, eosinophilia. Chronic - pulmonary (cough, discolored sputum), clusters of reddish-brown eggs (NOT blood), may persist 20 yrs
Term
P. westermani - Dx
Definition
Eggs in stool/sputum 2-3mo after infection, immunoDx to differentiate from TB
Term
P. westermani - Tx
Definition
Praziquantel
Term
Faciola hepatica - name, mode xmit, classification
Definition
Liver fluke, ingestion, tissue disease
Term
F. hepatica - geographical distribution
Definition
Europe, Middle East, Africa (where raw watercress is eaten)
Term
F. hepatica - intermediate/definitive host, life cycle
Definition
Eggs shed in stool, ingested by SNAIL (intermediate host), cercariae go to water plants --> metacercariae, can be ingested by HUMANS, SHEEP, CATTLE (Definitive hosts)
Term
F. hepatica - infectious form
Definition
Metacercariae on water plants (uncooked vegetables)
Term
F. hepatica - migration in humans
Definition
To duodenum & hepatic biliary ducts
Term
F. hepatica - Sx (Acute and chronic)
Definition
Acute - diarrhea, abdominal pain, fever, vomiting, enlarged liver; Chronic - bile duct blockage & inflammation
Term
F. hepatica - Dx
Definition
Eggs in stool (broad ellipsoid, thin operculum at one end)
Term
F. hepatica - Tx
Definition
Triclabendizole
Term
Cercarial dermatitis - classification
Definition
Contact --> tissue infection (wander worm, wrong host)
Term
Cercarial dermatitis - intermediate/defintive hosts
Definition
Definitive host in BIRDS, intermediate host is MOLLUSKS. Water-borne cercariae can penetrate HUMANS (dead-end host)
Term
Cercarial dermatitis - Sx
Definition
Local red spot increases in size over 4-7d, can be treated with anti-inflamms
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