Term
best anti-septic coverage? |
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Definition
Chlorhexadine > betadine (no fungal coverage) |
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Term
Anti-virals -tx for HSV -CMV |
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Definition
HSV = Acyclovir
CMV = Ganciclovir |
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Term
Anti TB drugs -INH tox/prevention |
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Definition
-hepatotox -periph neuropathy (prevent w/B6) |
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Term
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Definition
1. hepatotox = INH, Rifamp, Pyrazinamide 2. periph neuro = INH 3. Retrobulbar neuritis = ethambultol 4. Oto/nephrotox = Streptomycin |
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Term
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Definition
1. INH = cell wall (mycolic acids) 2. Rif = RNA polymerase 3. Pyrazinamide = cell wall (arabinogalactan) 4. Ethambutol = inhibit FA synth 5. Streptomycin = small ribo sub-unit (30S) |
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Term
Amphotercin how to diminish SE? |
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Definition
liposomal form -renal tox (DI) -hepatotox, anemia, hypoK |
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Term
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Definition
*anidulafungin* -cell wall glucan inhibitor -few SE, undergoes spont degredation |
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Term
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Definition
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Term
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Definition
fungal p450 inhibitor ==| ergosterol |
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Term
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Definition
Itraconazole = more broad specturm |
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Term
invasive aspergillposis tx |
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Definition
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Term
Drug dose adjustment @ peak vs trough too high |
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Definition
peak = dec amount
trough = dec frequency |
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Term
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Definition
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Term
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Definition
ferredoxin = active metab -O2 radical formation |
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Term
Common clinda indications |
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Definition
-Asp pna (anaerobic coverage) -C perfringens |
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Term
drug combo to avoid w/macrolides? |
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Definition
macro + statin -periph neuropathy |
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Term
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Definition
erythrom azithro clarithromycin |
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Term
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Definition
QT prolongation Nausea w/PO Cholestasis w/IV |
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Term
Amingolycoside -resistance mech |
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Definition
decreased active transport |
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Term
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Definition
reversible nephrotox irreversible ototox |
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Term
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Definition
*-floxacin* -tendon rupture -periph neuro |
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Term
what facilitates aminoglycoside uptake? |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
change in cell wall binding site |
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Term
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Definition
2/2 vanc -->histamine release |
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Term
% w/penicillin allergy that have cephalosporin allergy? |
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Definition
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Term
coverage differences between cephalosporin generations |
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Definition
1st = GPCs. No CNS penetration 2nd = GPC + GNR 3rd = GNRs |
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Term
list first gen cephalosporins |
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Definition
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Term
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Definition
cefoxitin cefotetan cefuroxime |
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Term
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Definition
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Term
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Definition
oxa, naf, methicillin -beta lactamase resistant |
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Term
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Definition
ampicillin amoxicillin (have enerococci coverage) |
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Term
combo amino-penicillin drugs |
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Definition
*beta-lactamase inhibitors* ampicillin + sUlbactam = Unasyn amoxicillin + clavulanic acid = Augmentin |
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Term
extended spectrum penicillins = |
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Definition
ticarcillin, piperacillin |
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Term
Zosyn = piperacillin + sulbactam |
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Definition
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Term
what abx are ineffective in presence of beta-lactamase? |
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Definition
PCN cephalosporin monobactams carbapenems |
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Term
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Definition
dec active transport into cell |
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Term
fluoroquin resistance mech? |
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Definition
DNA gyrase mutation = can't bind |
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Term
macrolid resistance mech? |
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Definition
ribosomal subunit mutation= can't bind |
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Term
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Definition
nitroreductase gene/plasmid = drug is taken up and reduced w/out formation of damaging nitro-radicals *nitro or O2 radicals??* |
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Term
MRSA / VRE resistance mech? |
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Definition
alterations in cell wall binding protein |
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Term
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Definition
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Term
bugs that use beta-lactamse for MDR |
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Definition
klebsiella serratia enterobacter |
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Term
Inhibitors of cell wall synth -list |
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Definition
Penicillins Cephalosporins Carapenems Monobactams Vanc |
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Term
Small subunit ribosome inhibitors |
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Definition
tetracyclines aminoglycosides (IRREV) Linezolid (IRREV) |
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Term
Large ribosome subunit inhibitors |
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Definition
Macrolides Clinda Chloramphenicol Synercid (irrev) |
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Term
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Definition
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Term
RNA polymerase inhibitors |
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Definition
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Term
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Definition
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Term
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Definition
PABA analogue -inhibits purine synth |
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Term
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Definition
DHFR inhibitor -inhib purine synth |
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Term
What abx are baceriostatic ? |
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Definition
chloramphenicol Tetracycline Clinda Macrolides Bactrim *all others = bacteriocidal* |
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