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The Elements of Chemotherapy
Drugs, Microbes, Host
14
Microbiology
Undergraduate 3
04/08/2014

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Cards

Term
Macrolide Polyene
Definition
mimic lipids, most versatile and effective, topical and systemic treatments
Term
griseofulvin
Definition
cases of dermatophyte infections, nephrotoxic
Term
synthetic azoles
Definition
broad spectrum; clotrimazole, miconazole
Term
flucytosine
Definition
analog of cytosine; cutaneous mycoses
Term
echinocandins
Definition
damage cell walls
Term
antimalarial drugs
Definition
quinine, chloroquinine, primaquine, mefloquine
Term
antiprotozoan drugs
Definition
metroniazole, quinirine, sulfonamides, tetracyclines
Term
antihelminthic drugs
Definition
immobilize, disintegrate, or inhibit metabolism
Term
antiviral chemotherapeutic agents
Definition
no selective toxicity, block penetration to host cell, transcription, translation; prevent maturation of viral particles
Term
interferons
Definition
human based glycoprotein produced primarily by fibroblasts and leukocytes
Term
acquisition of drug resistance
Definition
Adaptive response in which microorganisms begin to tolerate an amount of drug that would ordinarily be inhibitory
Term
natural selection
Definition
process by which organisms better adapted for the environment survive and reproduce
Term
superinfections
Definition
disruption in the balance of the normal flora
Term
therapeutic index
Definition
the ratio of the dose of the drug that is toxic to humans as compared to its minimum effective dose (high index is desirable)
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